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Eutirox (Thyroxine) 100 mcg/tab

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Base price $10.17
Description

White, round tablets, flat on both sides with a chamfer. On both sides of the tablets is the separation of risk, on one side of the tablet is engraved "EAT + dosage". Pharmacological action Pharmacological action — makes up for the deficiency of thyroid hormones. Pharmacodynamics Synthetic levo isomer of thyroxine.

After the partial conversion to triiodothyronine (in the liver and kidneys) and enter the body's cells affects the development and growth of tissues, metabolism. In small doses has anabolic effect on protein and fat metabolism in medium — stimulated growth and development increases the demand of tissues in oxygen, stimulates the metabolism of proteins, fats and carbohydrates, increases the functional activity of the cardiovascular system and Central nervous system, in large — inhibits the production of thyrotropin-releasing hormone from the hypothalamus and TSH from the pituitary gland. The therapeutic effect develops after 7-12 days and stored in the same time after drug withdrawal.

Clinical effect in hypothyroidism is manifested in 3-5 days. Diffuse goiter decreases or disappears within 3-6 months. Pharmacokinetics When administered levothyroxine sodium is absorbed mainly in the upper part of the small intestine (up to 80% of the dose).

eating reduces the absorption of levothyroxine. Cmax in plasma is reached after about 5-6 h after administration.

After absorption of more than 99% of drug binds to serum proteins (thyroxine-binding globulin, thyroxine binding by prealbumin and albumin). In various tissues montelaterone approximately 80% of levothyroxine with the formation of triiodothyronine (T3) and inactive products. Thyroid hormones are metabolized primarily in the liver, kidney, brain and muscles.

a Small amount of drug undergoes deamination and decaрбоксилированию, and conjugation with sulfuric and glucuronic acids (in the liver). The metabolites are excreted by the kidneys and through the intestines.

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