ANASTRAZOLUS 20tab/1mg

Print
anastrazolus-20tab1mg.jpganastrazolus-20tab1mg.jpg
Base price $10.94
Description Brief description of the drug:

Activity : 48 hours
Classification : aromatase Inhibitor (oral)
Dosage : 0,25-1 mg/day.
Acne : Yes
water retention : No
High blood pressure : May decrease if used aromatizers steroids
Hepatotoxicity : Yes
Suppression of HPTA function : No

Pharmacological action

Selective non-steroidal aromatase inhibitor. Aromatase - an enzyme with which post-menopausal women Androstenedione in peripheral tissues is converted to estrone and then to estradiol. Reduction of circulating levels of estradiol exerts a therapeutic effect in patients with breast cancer. In postmenopausal women the drug in a daily dose of 1 mg causes a decrease in estradiol levels by 80%. arimidex does not possess progestogenic, androgenic and estrogenic activity. arimidex at a daily dose of 10 mg has no effect on the secretion of cortisol and aldosterone (hence, the application of the substitution drug is not required for the introduction of corticosteroids).

Pharmacokinetics

Absorption After oral intake, anastrozole is rapidly absorbed from the gastrointestinal tract. Cmax in plasma achieved within 2 h (fasting). Food slightly reduces the rate but not extent of absorption. Small changes in suction speed must not lead to clinically significant impact on Par in plasma at a daily intake of 1 tablet. arimidex. Distribution anastrozole is bound to plasma proteins 40%. Approximately 90-95% of CSS is achieved after 7 days of treatment. There is no information on drug accumulation and dependency of pharmacokinetic parameters anastrozole from time to time and dose. Metabolism anastrozole is metabolized by N-dealkilirovania, hydroxylation and glucuronidation. Triazole, the major metabolite identified in plasma and urine, does not inhibit aromatase. Elimination of anastrozole is excreted slowly, T1/2 is the 40-50 h. anastrozole and its metabolites are excreted mainly with urine (less than 10% of the derived dose in an unmodified form) within 72 h after administration of the drug. Pharmacokinetics in special clinical cases Defined by the clearance of anastrozole after oral administration in volunteers with stable hepatic cirrhosis or impaired renal function are not different from the clearance determined in healthy volunteers. The pharmacokinetics of anastrozole is not dependent on age in postmenopausal women.

the Mode

for Adults, including elderly patients, the drug is administered 1 mg orally 1 times/day. Patients with mild and moderately severe disorders of the liver and kidneys do not require dose adjustments. Side effects From the endocrine system: hot flashes, vaginal dryness, thinning of the hair. From the digestive system: anorexia, nausea, vomiting, diarrhea, a slight rise of the total cholesterol. In patients with liver metastases and/or bone - increasing the level of GGT, alkaline phosphatase less (causal relationship of these changes with taking arimidex were not installed). CNS: drowsiness, headache. Dermatological reactions: rash. Other: asthenia, arthralgia, reduced mobility of joints. Vaginal bleeding was observed infrequently, mainly in patients during the first few weeks of taking arimidex after the abolition of prior hormonal therapy. By constant vaginal bleeding needs further examination.The dosage regimen for Adults, including elderly patients, the drug is administered 1 mg orally 1 times/day. Patients with mild and moderately severe disorders of the liver and kidneys do not require dose adjustments.

Side effects

From the endocrine system: hot flashes, vaginal dryness, thinning of the hair. From the digestive system: anorexia, nausea, vomiting, diarrhea, a slight rise of the total cholesterol. In patients with liver metastases and/or bone - increasing the level of GGT, alkaline phosphatase less (causal relationship of these changes with taking arimidex were not installed). CNS: drowsiness, headache. Dermatological reactions: rash. Other: asthenia, arthralgia, reduced mobility of joints. Vaginal bleeding was observed infrequently, mainly in patients during the first few weeks of taking arimidex after the abolition of prior hormonal therapy. By constant vaginal bleeding needs further examination.

Reviews

There are yet no reviews for this product.

Please publish modules in offcanvas position.