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Gonadotropin 5 vials of 1000 I.U.

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Base price $28.02
Description

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics. Human chorionic Gonadotropin (HCG) - hCG hormone, which is produced by the placenta during pregnancy, and then in an unmodified form excreted by the kidneys. For obtaining of the drug is extracted from urine and purified. Necessary for normal growth and maturation of gametes in females and males, as well as for production of sex hormones.

Has a gonadotropic effect, FSH and LH. Luteinizing activity prevails over it. Stimulates development of sex organs and secondary sexual characteristics. In women, the drug causes ovulation and stimulates the synthesis of estrogen (estradiol) and progesterone. In males - stimulates spermatogenesis, the production of testosterone and dihydrotestosterone.

the Pharmacokinetics. After intramuscular injection is well absorbed. The half-life is 8 h. the Maximum concentration of HCG in the blood plasma is reached after 4-12 hours. The half-life of human chorionic gonadotropin is 29-30 hours, in the case of daily intramuscular injections may be the accumulation of the drug. Chorionic Gonadotropin is excreted by the kidneys. About 10-20% of the administered dose found in the urine in an unmodified form, the main part is excreted in the form of fragments of β-chain.

INDICATIONS FOR USE

women:

- ovarian dysfunction (anovulatory), amenorrhea;

- the maintenance phase of the corpus luteum;

men and boys

- hypogonadotropic hypogonadism;

- the delay of puberty due to insufficient gonadotropic pituitary function;

- cryptorchidism, not due to anatomical obstruction;

- a failure of spermatogenesis, oligo-asthenospermia azoospermia;

- when conducting a differential diagnostic test anorchia and cryptorchidism in boys;

- when conducting a functional test, Surg to assess testicular function in hypogonadotropic hypogonadism before starting long-term stimulant treatment.

METHOD of APPLICATION AND DOSES

After adding the solvent to the lyophilisate reconstituted solution of human chorionic gonadotropin is administered intramuscularly, slowly. The prepared solution must not be stored, because the further preserve the sterility of the solution is not guaranteed. These dosages are approximate, treatment should be adjusted individually depending on the required reaction to the drug.

women:

- when anovulatory cycles human chorionic Gonadotropin is prescribed starting from 10-12 days of the menstrual cycle at 3000 ME 2-3 times with an interval of 2-3 days or 1,500 ME 6-7 times a day;

- to maintain the phase of the corpus luteum can be done two to three repeated injections of the drug at a dose of from 1500 to 5000 ME ME each within 9 days after ovulation or embryo transfer (for example, 3, 6 and day 9 after ovulation induction).

men and boys

- if the hypogonadotropic hypogonadism 1000-2000 IU of the drug 2-3 times a week. In the case of infertility, the combination chorionic gonadotropin with additional product containing follitropin (follicle stimulating hormone), 2-3 times a week. The course of treatment should last at least 3 months when you can expect any improvement in spermatogenesis. During this treatment to keep testosterone replacement therapy. When the improvement of spermatogenesis achieved, to maintain it is sufficient, in some cases, the isolated application of human chorionic gonadotropin;

- with delayed sexual maturation caused by deficiency of gonadotropic function of the pituitary gland - 1500 ME 2-3 times a week. The course of treatment - not less than 6 months;

- when cryptorchidism not due to anatomical obstruction: ages 3 to 6 years - 500-1000 ME twice a week for 6 weeks; at the age of 6 years - 1500 ME twice a week for 6 weeks. The course of treatment if necessary can be repeated.

- when failure of spermatogenesis, oligoastenospermii, azoospermia prescribed ME 500 in combination with menotropins (75 ME follicle-stimulating hormone and 75 ME of luteinizing hormone) daily, or 2000 ME every 5 days in combination with menotropinami (150 ME follicle-stimulating hormone + 150 ME luteinizing hormone) 3 times a week for 3 months. In the absence of reaction to the treatment administered 2000 ME 2-3 times a week menotropinam (150 ME follicle-stimulating hormone +150 ME luteinizing hormone) 3 times weekly for 3-12 months. Upon reaching the subsequent improvement of spermatogenesis therapy in some cases can only be supportive doses of human chorionic gonadotropin;

- with the purpose of differential diagnosis of cryptorchidism and anorchia in boys, human chorionic Gonadotropin is injected intramuscularly once at the dose of 100 IU/kg, the concentration of testosterone in the serum is determined before the start of the test and after 72-96 h after injection. In the case of anorchia test will be negative, indicating the absence of testicular tissue, in the case of cryptorchidism, even if there is only one testicle, positive (5-10-fold increase in the concentrations of testosterone). If the test is weakly positive, it is necessary to search the gonads (ultrasound examination of the abdomen or laparoscopy) because of a high risk of malignancy.

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