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Ketofithene 30 tab /1 mg

Base price $3.11
Description Description

tablets are white or almost white, biconvex.

Pharmacological action

drugs, membrane stabilizing, anti-allergic, antihistaminic, anti-asthmatic. Inhibits the release of histamine and other mediators (such as slow reacting substance of anaphylaxis, lymphokines) from mast cells and basophils. Non-competitive blocking H1-histamine receptors, inhibits phosphodiesterase, increases cyclic adenosine monophosphate in the cells that blocks the calcium channels of cells, is a functional antagonist of the leukotrienes. Suppresses sensitization of eosinophils with cytokines, inhibits eosinophilic infiltration into areas of allergic inflammation in the respiratory tract. Prevents the development of symptoms airway hyperresponsiveness caused by platelet-activating factor or influence allergens. Prevents the development of bronchospasm (bronchodilator has no action). Has a depressant effect on the Central nervous system.

Indications for use

Prevention and treatment of Multisystem allergic disorders:

chronic idiopathic urticaria (e.g., cold urticaria);

- allergic rhinitis with concomitant asthma or without it;

- allergic conjunctivitis;

atopic dermatitis.

the Use of the Ketotifen does not replace treatment with corticosteroids (inhaled or systemic) if corticosteroids are indicated for the treatment of asthma.

Method of application and doses

the Drug is taken orally during meals.

Adults appoint 1 mg (1 tablet) twice a day (morning and evening).

in patients prone to sedation, it is recommended that a slow increase in dose over the first week. It is recommended to start taking 1 tablet once a day and increase the dose over 5 days to a full daily dose. If necessary, the daily dose can be increased to 4 mg (4 tablets) and split into two doses. When you use the higher doses you can expect faster onset of effect.

Children over the age of 3 years appoint 1 mg (1 tablet) twice a day (morning and evening). Given that in the study of pharmacokinetics showed high metabolic rate the ketotifen, in children may require a higher dose of the drug per kilogram of body weight for optimum effect. The tolerability of such doses is good.

Concurrent administration of bronchodilators. When taking the ketotifen frequency receiving bronchodilators may be reduced.

Use in the elderly. In the appointment of ketotifen elderly dose adjustment is not required.

Duration of therapy

To achieve full therapeutic effect of ketotifen may take several months. In the case that for several weeks the patient noted a reaction to taking ketotifen, its further application to achieve a lasting effect should continue for at least 2-3 months. Cancel ketotifen should be done gradually over 2-4 weeks, with the possible aggravation of symptoms of allergic diseases.

Side effects

the incidence of side effects in the following gradation: very often (>1/10); often (≥1/100, <1/10); infrequently (≥1/1000, <1/100); rare (≥1/10000, <1/1000); very rare (<1/10000); not known (according to the available data to determine the frequency of occurrence is not possible).

From the Central nervous system: rare - dizziness, slowing of reaction (disappear after a few days of therapy), sedation, fatigue; rarely anxiety, sleep disorders, nervousness (especially in children); unknown - convulsions, drowsiness, and headache.

the immune system: very rarely - erythema multiforme, Stevens-Johnson syndrome, severe skin reactions.

the skin: not known - rash, hives.

the hematopoietic system: rarely – thrombocytopenia.

From the digestive system: rarely – increased appetite, dry mucous membranes of the oral cavity; rarely - dyspepsia; not known – nausea, vomiting, constipation, diarrhea.

in the liver: very rarely – hepatitis and elevated liver enzymes.

From the metabolic: rare – increase in weight.

From the urinary system: rare – dysuria, cystitis.


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